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https://doi.org/10.1016/j.tem.2007.10.008
Title: | Histone deacetylases and repression of the gonadotropin genes. | Authors: | Melamed, P. | Issue Date: | Jan-2008 | Citation: | Melamed, P. (2008-01). Histone deacetylases and repression of the gonadotropin genes.. Trends in endocrinology and metabolism: TEM 19 (1) : 25-31. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tem.2007.10.008 | Abstract: | The roles of chromatin modifications in transcription have been studied extensively; however, there remains a dearth of information explaining how extracellular signals induce changes in chromatin at a specific gene locus. The gonadotropins provide an example of genes that undergo significant fluctuations in their expression, and are regulated by gonadotropin-releasing hormone (GnRH) through a membrane-bound receptor. GnRH displaces histone deacetylases (HDACs) from gonadotropin genes in immature mouse gonadotropes, and some of the pathways have been elucidated. This GnRH effect likely comprises a mechanism involved in altering reproductive potential and provides a model for studying the regulation of derepression. This paper reviews the role of HDACs in repression of the gonadotropin genes and the mechanisms through which GnRH overcomes their actions. | Source Title: | Trends in endocrinology and metabolism: TEM | URI: | http://scholarbank.nus.edu.sg/handle/10635/102463 | ISSN: | 10432760 | DOI: | 10.1016/j.tem.2007.10.008 |
Appears in Collections: | Staff Publications |
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