Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tem.2007.10.008
Title: Histone deacetylases and repression of the gonadotropin genes.
Authors: Melamed, P. 
Issue Date: Jan-2008
Citation: Melamed, P. (2008-01). Histone deacetylases and repression of the gonadotropin genes.. Trends in endocrinology and metabolism: TEM 19 (1) : 25-31. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tem.2007.10.008
Abstract: The roles of chromatin modifications in transcription have been studied extensively; however, there remains a dearth of information explaining how extracellular signals induce changes in chromatin at a specific gene locus. The gonadotropins provide an example of genes that undergo significant fluctuations in their expression, and are regulated by gonadotropin-releasing hormone (GnRH) through a membrane-bound receptor. GnRH displaces histone deacetylases (HDACs) from gonadotropin genes in immature mouse gonadotropes, and some of the pathways have been elucidated. This GnRH effect likely comprises a mechanism involved in altering reproductive potential and provides a model for studying the regulation of derepression. This paper reviews the role of HDACs in repression of the gonadotropin genes and the mechanisms through which GnRH overcomes their actions.
Source Title: Trends in endocrinology and metabolism: TEM
URI: http://scholarbank.nus.edu.sg/handle/10635/102463
ISSN: 10432760
DOI: 10.1016/j.tem.2007.10.008
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