Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbagrm.2011.06.009
Title: Choreographing pluripotency and cell fate with transcription factors
Authors: Gonzales, K.A.U.
Ng, H.-H. 
Keywords: Pluripotency
Reprogramming
Stem cell
Transcription factor
Transdifferentiation
Issue Date: Jul-2011
Citation: Gonzales, K.A.U., Ng, H.-H. (2011-07). Choreographing pluripotency and cell fate with transcription factors. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1809 (7) : 337-349. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbagrm.2011.06.009
Abstract: The cellular identity of both pluripotent and differentiated cells is defined by the concerted interplay of transcriptional factors as well as other modulators such as epigenetic and signaling mediators. Therefore, the manipulation of a cell's transcriptional network directly facilitates inter-conversion between cellular identities. Understanding the molecular regulation of cell fate changes, including those involved in pluripotency, is crucial in realizing the practical potential of pluripotent and induced cell types. Here we review the advancements in the role of transcription factors in pluripotency, as well as in the conversion between and within pluripotent and somatic cell types. © 2011 Elsevier B.V.
Source Title: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
URI: http://scholarbank.nus.edu.sg/handle/10635/102418
ISSN: 18749399
DOI: 10.1016/j.bbagrm.2011.06.009
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