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Title: Centrins in unicellular organisms: Functional diversity and specialization
Authors: Zhang, Y.
He, C.Y. 
Keywords: Centrins
Protein structure-function
Unicellular organisms
Issue Date: Jul-2012
Citation: Zhang, Y., He, C.Y. (2012-07). Centrins in unicellular organisms: Functional diversity and specialization. Protoplasma 249 (3) : 459-467. ScholarBank@NUS Repository.
Abstract: Centrins (also known as caltractins) are conserved, EF hand-containing proteins ubiquitously found in eukaryotes. Similar to calmodulins, the calcium-binding EF hands in centrins fold into two structurally similar domains separated by an alpha-helical linker region, shaping like a dumbbell. The small size (15-22 kDa) and domain organization of centrins and their functional diversity/specialization make them an ideal system to study protein structure-function relationship. Here, we review the work on centrins with a focus on their structures and functions characterized in unicellular organisms. © 2011 Springer-Verlag.
Source Title: Protoplasma
ISSN: 0033183X
DOI: 10.1007/s00709-011-0305-2
Appears in Collections:Staff Publications

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