Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.conb.2014.04.005
Title: Axon and dendrite pruning in Drosophila
Authors: Yu, F. 
Schuldiner, O.
Issue Date: 2014
Citation: Yu, F., Schuldiner, O. (2014). Axon and dendrite pruning in Drosophila. Current Opinion in Neurobiology 27 : 192-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.conb.2014.04.005
Abstract: Pruning, a process by which neurons selectively remove exuberant or unnecessary processes without causing cell death, is crucial for the establishment of mature neural circuits during animal development. Yet relatively little is known about molecular and cellular mechanisms that govern neuronal pruning. Holometabolous insects, such as Drosophila, undergo complete metamorphosis and their larval nervous systems are replaced with adult-specific ones, thus providing attractive models for studying neuronal pruning. Drosophila mushroom body and dendritic arborization neurons have been utilized as two appealing systems to elucidate the underlying mechanisms of axon and dendrite pruning, respectively. In this review we highlight recent developments and discuss some similarities and differences in the mechanisms that regulate these two distinct modes of neuronal pruning in Drosophila. © 2014 Elsevier Ltd.
Source Title: Current Opinion in Neurobiology
URI: http://scholarbank.nus.edu.sg/handle/10635/102409
ISSN: 18736882
DOI: 10.1016/j.conb.2014.04.005
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