Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2004.12.055
Title: Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control
Authors: Lua, B.L.
Low, B.C. 
Keywords: Actin cytoskeleton
Cortactin
Erk
Kinase
Phosphorylation
Src
Issue Date: 31-Jan-2005
Citation: Lua, B.L., Low, B.C. (2005-01-31). Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Letters 579 (3) : 577-585. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2004.12.055
Abstract: Cortactin is an important molecular scaffold for actin assembly and organization. Novel mechanistic functions of cortactin have emerged with more interacting partners identified, revealing its multifaceted roles in regulating actin cytoskeletal networks that are necessary for endocytosis, cell migration and invasion, adhesion, synaptic organization and cell morphogenesis. These processes are mediated by its multi-domains binding to F-actin and Arp2/3 complex and various SH3 targets. Furthermore, its role in actin remodeling is subjected to regulation by tyrosine and serine/threonine kinases. Elucidating the mechanisms underlying cortactin phosphorylation and its functional consequences would provide new insights to various aspects of cell dynamics control. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/102303
ISSN: 00145793
DOI: 10.1016/j.febslet.2004.12.055
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