Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mce.2006.03.024
Title: Transcription of gonadotropin β subunit genes involves cross-talk between the transcription factors and co-regulators that mediate actions of the regulatory hormones
Authors: Melamed, P. 
Kadir, M.N.A.
Wijeweera, A.
Seah, S.
Keywords: Acetylation
Activin
Chromatin
Co-activator
Co-repressor
Deacetylation
Estrogen
Follicle-stimulating hormone
Gonadotropin-releasing hormone
Luteinizing hormone
Steroids
Testosterone
Transcription
Issue Date: 27-Jun-2006
Citation: Melamed, P., Kadir, M.N.A., Wijeweera, A., Seah, S. (2006-06-27). Transcription of gonadotropin β subunit genes involves cross-talk between the transcription factors and co-regulators that mediate actions of the regulatory hormones. Molecular and Cellular Endocrinology 252 (1-2) : 167-183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mce.2006.03.024
Abstract: The gonadotropins LH and FSH have distinct temporal patterns of expression as a result of differential regulation by hormones such as GnRH, steroids and activin. This specific regulation is due to diverse sets of transcription factors that are recruited to the promoters of these genes, and recruit specific co-activator complexes which function to stabilize interactions with the general transcription factors and RNA polymerase II, and also to induce covalent modifications of the histone tails at these gene loci. As these molecular mechanisms are elucidated, the nature of nuclear cross-talk between the various hormonally induced pathways is becoming evident, revealing both negative and positive effects of interacting transcription factors and co-regulators. This paper will review current knowledge on the transcriptional regulation of gonadotropin β subunit gene expression in the chromatin setting, and will present new data pertaining to nuclear cross-talk between the various endocrine-induced pathways regulating gonadotropin gene transcription. © 2006 Elsevier Ireland Ltd. All rights reserved.
Source Title: Molecular and Cellular Endocrinology
URI: http://scholarbank.nus.edu.sg/handle/10635/102057
ISSN: 03037207
DOI: 10.1016/j.mce.2006.03.024
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

34
checked on Oct 17, 2020

WEB OF SCIENCETM
Citations

30
checked on Oct 9, 2020

Page view(s)

67
checked on Oct 10, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.