Please use this identifier to cite or link to this item: https://doi.org/10.1126/science.1112631
DC FieldValue
dc.titleThe genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
dc.contributor.authorEl-Sayed, N.M.
dc.contributor.authorMyler, P.J.
dc.contributor.authorBartholomeu, D.C.
dc.contributor.authorNilsson, D.
dc.contributor.authorAggarwal, G.
dc.contributor.authorTran, A.-N.
dc.contributor.authorGhedin, E.
dc.contributor.authorWorthey, E.A.
dc.contributor.authorDelcher, A.L.
dc.contributor.authorBlandin, G.
dc.contributor.authorWestenberger, S.J.
dc.contributor.authorCaler, E.
dc.contributor.authorCerqueira, G.C.
dc.contributor.authorBranche, C.
dc.contributor.authorHaas, B.
dc.contributor.authorAnupama, A.
dc.contributor.authorArner, E.
dc.contributor.authorÅslund, L.
dc.contributor.authorAttipoe, P.
dc.contributor.authorBontempi, E.
dc.contributor.authorBringaud, F.
dc.contributor.authorBurton, P.
dc.contributor.authorCadag, E.
dc.contributor.authorCampbell, D.A.
dc.contributor.authorCarrington, M.
dc.contributor.authorCrabtree, J.
dc.contributor.authorDarban, H.
dc.contributor.authorDa Silveira, J.F.
dc.contributor.authorDe Jong, P.
dc.contributor.authorEdwards, K.
dc.contributor.authorEnglund, P.T.
dc.contributor.authorFazelina, G.
dc.contributor.authorFeldblyum, T.
dc.contributor.authorFerella, M.
dc.contributor.authorFrasch, A.C.
dc.contributor.authorGull, K.
dc.contributor.authorHorn, D.
dc.contributor.authorHou, L.
dc.contributor.authorHuang, Y.
dc.contributor.authorKindlund, E.
dc.contributor.authorKlingbeil, M.
dc.contributor.authorKluge, S.
dc.contributor.authorKoo, H.
dc.contributor.authorLacerda, D.
dc.contributor.authorLevin, M.J.
dc.contributor.authorLorenzi, H.
dc.contributor.authorLouie, T.
dc.contributor.authorMachado, C.R.
dc.contributor.authorMcCulloch, R.
dc.contributor.authorMcKenna, A.
dc.contributor.authorMizuno, Y.
dc.contributor.authorMottram, J.C.
dc.contributor.authorNelson, S.
dc.contributor.authorOchaya, S.
dc.contributor.authorOsoegawa, K.
dc.contributor.authorPai, G.
dc.contributor.authorParsons, M.
dc.contributor.authorPentony, M.
dc.contributor.authorPettersson, U.
dc.contributor.authorPop, M.
dc.contributor.authorRamirez, J.L.
dc.contributor.authorRinta, J.
dc.contributor.authorRobertson, L.
dc.contributor.authorSalzberg, S.L.
dc.contributor.authorSanchez, D.O.
dc.contributor.authorSeyler, A.
dc.contributor.authorSharma, R.
dc.contributor.authorShetty, J.
dc.contributor.authorSimpson, A.J.
dc.contributor.authorSisk, E.
dc.contributor.authorTammi, M.T.
dc.contributor.authorTarleton, R.
dc.contributor.authorTeixeira, S.
dc.contributor.authorVan Aken, S.
dc.contributor.authorVogt, C.
dc.contributor.authorWard, P.N.
dc.contributor.authorWickstead, B.
dc.contributor.authorWortman, J.
dc.contributor.authorWhite, O.
dc.contributor.authorFraser, C.M.
dc.contributor.authorStuart, K.D.
dc.contributor.authorAndersson, B.
dc.date.accessioned2014-10-27T08:42:34Z
dc.date.available2014-10-27T08:42:34Z
dc.date.issued2005-07-15
dc.identifier.citationEl-Sayed, N.M., Myler, P.J., Bartholomeu, D.C., Nilsson, D., Aggarwal, G., Tran, A.-N., Ghedin, E., Worthey, E.A., Delcher, A.L., Blandin, G., Westenberger, S.J., Caler, E., Cerqueira, G.C., Branche, C., Haas, B., Anupama, A., Arner, E., Åslund, L., Attipoe, P., Bontempi, E., Bringaud, F., Burton, P., Cadag, E., Campbell, D.A., Carrington, M., Crabtree, J., Darban, H., Da Silveira, J.F., De Jong, P., Edwards, K., Englund, P.T., Fazelina, G., Feldblyum, T., Ferella, M., Frasch, A.C., Gull, K., Horn, D., Hou, L., Huang, Y., Kindlund, E., Klingbeil, M., Kluge, S., Koo, H., Lacerda, D., Levin, M.J., Lorenzi, H., Louie, T., Machado, C.R., McCulloch, R., McKenna, A., Mizuno, Y., Mottram, J.C., Nelson, S., Ochaya, S., Osoegawa, K., Pai, G., Parsons, M., Pentony, M., Pettersson, U., Pop, M., Ramirez, J.L., Rinta, J., Robertson, L., Salzberg, S.L., Sanchez, D.O., Seyler, A., Sharma, R., Shetty, J., Simpson, A.J., Sisk, E., Tammi, M.T., Tarleton, R., Teixeira, S., Van Aken, S., Vogt, C., Ward, P.N., Wickstead, B., Wortman, J., White, O., Fraser, C.M., Stuart, K.D., Andersson, B. (2005-07-15). The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease. Science 309 (5733) : 409-415+435. ScholarBank@NUS Repository. https://doi.org/10.1126/science.1112631
dc.identifier.issn00368075
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101923
dc.description.abstractWhole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1126/science.1112631
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1126/science.1112631
dc.description.sourcetitleScience
dc.description.volume309
dc.description.issue5733
dc.description.page409-415+435
dc.description.codenSCIEA
dc.identifier.isiut000230574900035
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

974
checked on Aug 3, 2020

WEB OF SCIENCETM
Citations

965
checked on Aug 3, 2020

Page view(s)

81
checked on Aug 1, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.