Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.emboj.7600533
Title: The ancient origin of the complement system
Authors: Zhu, Y. 
Thangamani, S. 
Ho, B.
Ding, J.L. 
Keywords: Complement
Evolution
Innate immunity
Protostome
Issue Date: 26-Jan-2005
Citation: Zhu, Y., Thangamani, S., Ho, B., Ding, J.L. (2005-01-26). The ancient origin of the complement system. EMBO Journal 24 (2) : 382-394. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.emboj.7600533
Abstract: The complement system has been thought to originate exclusively in the deuterostomes. Here, we show that the central complement components already existed in the primitive protostome lineage. A functional homolog of vertebrate complement 3, CrC3, has been isolated from a 'living fossil', the horseshoe crab (Carcinoscorpius rotundicauda). CrC3 resembles human C3 and shows closest homology to C3 sequences of lower deuterostomes. CrC3 and plasma lectins bind a wide range of microbes, forming the frontline innate immune defense system. Additionally, we identified CrC2/Bf, a homolog of vertebrate C2 and Bf that participates in C3 activation, and a C3 receptor-like sequence. Furthermore, complement-mediated phagocytosis of bacteria by the hemocytes of horseshoe crab was also observed. Thus, a primitive yet complex opsonic complement defense system is revealed in the horseshoe crab, a protostome species. Our findings demonstrate an ancient origin of the critical complement components and the opsonic defense mechanism in the Precambrian ancestor of bilateral animals.
Source Title: EMBO Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/101860
ISSN: 02614189
DOI: 10.1038/sj.emboj.7600533
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

177
checked on Oct 14, 2019

WEB OF SCIENCETM
Citations

172
checked on Oct 7, 2019

Page view(s)

57
checked on Oct 12, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.