Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.014324
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dc.titleTbG63, a golgin involved in Golgi architecture in Trypanosoma brucei
dc.contributor.authorRamirez, I.B.-R.
dc.contributor.authorde Graffenried, C.L.
dc.contributor.authorEbersberger, I.
dc.contributor.authorYelinek, J.
dc.contributor.authorHe, C.Y.
dc.contributor.authorPrice, A.
dc.contributor.authorWarren, G.
dc.date.accessioned2014-10-27T08:41:27Z
dc.date.available2014-10-27T08:41:27Z
dc.date.issued2008-05-01
dc.identifier.citationRamirez, I.B.-R., de Graffenried, C.L., Ebersberger, I., Yelinek, J., He, C.Y., Price, A., Warren, G. (2008-05-01). TbG63, a golgin involved in Golgi architecture in Trypanosoma brucei. Journal of Cell Science 121 (9) : 1538-1546. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.014324
dc.identifier.issn00219533
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101829
dc.description.abstractGolgins are coiled-coil proteins that have been implicated in the structure and function of the Golgi complex. Here, we identify and characterize a trypanosomal golgin, TbG63, showing that it has a C-terminal membrane anchor and an N-terminus that projects into the cytoplasm. TbG63 in procyclic parasites is localized to the Golgi and interacts with the active, GTP-form of TbRab1A. Overexpression of TbG63 has dramatic effects on Golgi architecture - effects that require the N-terminus - whereas depletion has little, if any, effect on the growth rate. By contrast, in the bloodstream form of the parasite, depletion of TbG63 slows growth, although it has no obvious effect on the transport of a variant surface glycoprotein (VSG) or on Golgi structure. TbG63 might be a useful tool to study the structure and functioning of the Golgi complex.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1242/jcs.014324
dc.sourceScopus
dc.subjectArchitecture
dc.subjectBrucei
dc.subjectGolgi
dc.subjectGolgin
dc.subjectGTPase
dc.subjectMorphology
dc.subjectRab
dc.subjectTrypanosome
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1242/jcs.014324
dc.description.sourcetitleJournal of Cell Science
dc.description.volume121
dc.description.issue9
dc.description.page1538-1546
dc.description.codenJNCSA
dc.identifier.isiut000255269300021
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