Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2007.02.079
Title: Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats
Authors: Yu, X.-Y.
Lin, S.-G.
Zhou, Z.-W.
Chen, X.
Liang, J.
Duan, W.
Yu, X.-Q.
Wen, J.-Y.
Chowbay, B.
Li, C.-G.
Sheu, F.-S. 
Chan, E. 
Zhou, S.-F.
Keywords: Focal infarct
Middle cerebral artery occlusion
Rat
Stroke
Tanshinone IIB
Issue Date: 7-May-2007
Citation: Yu, X.-Y., Lin, S.-G., Zhou, Z.-W., Chen, X., Liang, J., Duan, W., Yu, X.-Q., Wen, J.-Y., Chowbay, B., Li, C.-G., Sheu, F.-S., Chan, E., Zhou, S.-F. (2007-05-07). Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats. Neuroscience Letters 417 (3) : 261-265. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2007.02.079
Abstract: Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB. © 2007 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/101819
ISSN: 03043940
DOI: 10.1016/j.neulet.2007.02.079
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