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Title: Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines
Authors: Kumar, C.S.A.
Prasad, S.B.B.
Vinaya, K.
Chandrappa, S.
Thimmegowda, N.R.
Kumar, Y.C.S.
Swarup, S. 
Rangappa, K.S.
Keywords: 1-Benzhydrylpiperazine derivatives
Antiproliferative activity
Carcinoma cell lines
Cell proliferation
MTT assay
Sulfonyl chlorides
Issue Date: Mar-2009
Citation: Kumar, C.S.A., Prasad, S.B.B., Vinaya, K., Chandrappa, S., Thimmegowda, N.R., Kumar, Y.C.S., Swarup, S., Rangappa, K.S. (2009-03). Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. European Journal of Medicinal Chemistry 44 (3) : 1223-1229. ScholarBank@NUS Repository.
Abstract: In order to explore the antiproliferative effect associated with the piperazine framework, several 1-benzhydrylpiperazine derivatives 8(a-d), 9(a-d) and 10(a-h) were synthesized. Variation in the functional group at N-terminal of the piperazine led to three sets of compounds, bearing the sulfonyl, amide and thiourea, respectively. Their chemical structures were confirmed by 1H NMR, LCMS, IR and elemental analysis. The antiproliferative effect of the compounds were evaluated in vitro using the MTT colorimetric method against one normal cell line (NF-103 skin fibroblast cells) and four human cancer cell lines (MCF-7 breast carcinoma cell line, HepG-2 hepatocellular carcinoma cell line, HeLa cervix carcinoma cell line and HT-29 colon carcinoma cell line) for the time period of 24 h. Among the series, four compounds exhibited interesting growth inhibitory effects against all four cell lines. © 2008 Elsevier Masson SAS. All rights reserved.
Source Title: European Journal of Medicinal Chemistry
ISSN: 02235234
DOI: 10.1016/j.ejmech.2008.09.025
Appears in Collections:Staff Publications

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