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Title: Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives
Authors: Prasad, S.B.B.
Vinaya, M.K.
Kumar, C.K.S.A.
Swarup, S. 
Rangappa, K.S.
Keywords: Antiproliferative activity
Cancer therapy
Cell proliferation
MTT assay
Issue Date: Oct-2008
Citation: Prasad, S.B.B.,Vinaya, M.K.,Kumar, C.K.S.A.,Swarup, S.,Rangappa, K.S. (2008-10). Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives. Letters in Drug Design and Discovery 5 (7) : 454-461. ScholarBank@NUS Repository.
Abstract: A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-j) were synthesized and characterized by 1H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines namely HeLa, HT-29, MCF-7, HepG-2 by adopting positive and negative control. The importance of the methoxy and fluorine group on diphenyl(piperidin-4-yl)mefhanol moiety was confirmed and it was noted that, the substitution at 4th position of the aryl ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds, only (10a) and (10b) have potent antiproliferative activity on all the carcinoma cell lines tested. © 2008 Bentham Science Publishers Ltd.
Source Title: Letters in Drug Design and Discovery
ISSN: 15701808
DOI: 10.2174/157018008785909804
Appears in Collections:Staff Publications

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