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|Title:||Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives||Authors:||Prasad, S.B.B.
|Issue Date:||Oct-2008||Citation:||Prasad, S.B.B.,Vinaya, M.K.,Kumar, C.K.S.A.,Swarup, S.,Rangappa, K.S. (2008-10). Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives. Letters in Drug Design and Discovery 5 (7) : 454-461. ScholarBank@NUS Repository. https://doi.org/10.2174/157018008785909804||Abstract:||A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-j) were synthesized and characterized by 1H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines namely HeLa, HT-29, MCF-7, HepG-2 by adopting positive and negative control. The importance of the methoxy and fluorine group on diphenyl(piperidin-4-yl)mefhanol moiety was confirmed and it was noted that, the substitution at 4th position of the aryl ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds, only (10a) and (10b) have potent antiproliferative activity on all the carcinoma cell lines tested. © 2008 Bentham Science Publishers Ltd.||Source Title:||Letters in Drug Design and Discovery||URI:||http://scholarbank.nus.edu.sg/handle/10635/101797||ISSN:||15701808||DOI:||10.2174/157018008785909804|
|Appears in Collections:||Staff Publications|
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