Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.1103634108
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dc.titleStructure of Trypanosoma brucei flagellum accounts for its bihelical motion
dc.contributor.authorKoyfman, A.Y.
dc.contributor.authorSchmid, M.F.
dc.contributor.authorGheiratman, L.
dc.contributor.authorFu, C.J.
dc.contributor.authorKhant, H.A.
dc.contributor.authorHuang, D.
dc.contributor.authorHe, C.Y.
dc.contributor.authorChiu, W.
dc.date.accessioned2014-10-27T08:40:52Z
dc.date.available2014-10-27T08:40:52Z
dc.date.issued2011-07-05
dc.identifier.citationKoyfman, A.Y., Schmid, M.F., Gheiratman, L., Fu, C.J., Khant, H.A., Huang, D., He, C.Y., Chiu, W. (2011-07-05). Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. Proceedings of the National Academy of Sciences of the United States of America 108 (27) : 11105-11108. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.1103634108
dc.identifier.issn00278424
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101775
dc.description.abstractTrypanosoma brucei is a parasitic protozoan that causes African sleeping sickness. It contains a flagellum required for locomotion and viability. In addition to a microtubular axoneme, the flagellum contains a crystalline paraflagellar rod (PFR) and connecting proteins. We show here, by cryoelectron tomography, the structure of the flagellum in three bending states. The PFR lattice in straight flagella repeats every 56 nm along the length of the axoneme, matching the spacing of the connecting proteins. During flagellar bending, the PFR crystallographic unit cell lengths remain constant while the interaxial angles vary, similar to a jackscrew. The axoneme drives the expansion and compression of the PFR lattice. We propose that the PFR modifies the in-plane axoneme motion to produce the characteristic trypanosome bihelical motility as captured by high-speed light microscope videography.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1073/pnas.1103634108
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1073/pnas.1103634108
dc.description.sourcetitleProceedings of the National Academy of Sciences of the United States of America
dc.description.volume108
dc.description.issue27
dc.description.page11105-11108
dc.description.codenPNASA
dc.identifier.isiut000292376700040
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