Please use this identifier to cite or link to this item:
https://doi.org/10.1021/jm901469p
Title: | Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1 | Authors: | Bernardo, P.H. Sivaraman, T. Wan, K.-F. Xu, J. Krishnamoorthy, J. Sons, C.M. Tian, L. Chin, J.S.F. Lim, D.S.W. Mok, H.Y.K. Yu, V.C. Tong, J.C. Chai, C.L.L. |
Issue Date: | 11-Mar-2010 | Citation: | Bernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Sons, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2010-03-11). Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. Journal of Medicinal Chemistry 53 (5) : 2314-2318. ScholarBank@NUS Repository. https://doi.org/10.1021/jm901469p | Abstract: | The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity. © 2010 American Chemical Society. | Source Title: | Journal of Medicinal Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/101765 | ISSN: | 00222623 | DOI: | 10.1021/jm901469p |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
52
checked on May 24, 2022
WEB OF SCIENCETM
Citations
48
checked on May 24, 2022
Page view(s)
162
checked on May 12, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.