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Title: PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation
Authors: Ruan, K.
Ye, F.
Li, C.
Liou, Y.-C. 
Lin, S.-C.
Lin, S.-Y.
Issue Date: 14-Nov-2012
Citation: Ruan, K., Ye, F., Li, C., Liou, Y.-C., Lin, S.-C., Lin, S.-Y. (2012-11-14). PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation. PLoS ONE 7 (11) : -. ScholarBank@NUS Repository.
Abstract: Abnormal amplification of centrosomes could lead to improper chromosome segregation and aneuploidy and is implicated in cancer development. Here, we demonstrate that Axin, a scaffolding protein in Wnt signaling, is phosphorylated by PLK1 during mitosis. Phosphorylation of Axin Ser-157 by PLK1 abolished Axin association with γ-tubulin, while substitution of Ser-157 with alanine exhibited sustained interaction with γ-tubulin. In addition, overexpression of Axin-S157A significantly increased the number of cells with multi-centrosomes. These results suggest that the phosphorylation status of Axin, mediated by PLK1, dynamically regulates its association with γ-tubulin and centrosome formation and segregation. © 2012 Ruan et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0049184
Appears in Collections:Staff Publications

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