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|Title:||Nitric oxide enhances the capacitance of self-assembled, supported bilayer lipid membranes||Authors:||Ye, J.-S.
Planar lipid bilayer
Supported bilayer lipid membrane
|Issue Date:||2001||Citation:||Ye, J.-S., Ottova, A., Tien, H.T., Sheu, F.-S. (2001). Nitric oxide enhances the capacitance of self-assembled, supported bilayer lipid membranes. Electrochemistry Communications 3 (10) : 580-584. ScholarBank@NUS Repository. https://doi.org/10.1016/S1388-2481(01)00227-2||Abstract:||The effect of nitric oxide (NO) at biologically relevant concentrations on the electrochemical features of the membrane was investigated by cyclic voltammetry (CV) at self-assembled, stainless steel supported lipid bilayer membranes (s-BLMs) using a three-electrode system. The results showed that the membrane capacitance (Cm) of s-BLMs was dramatically enhanced by the presence of increasing NO concentration from 0 to 70 μM. For comparison, fullerene C60 doped s-BLMs (C60@s-BLMs) was also studied. The Cm of C60@s-BLMs increased with NO concentration from 0 to 16 μM and gradually reached a plateau value when NO concentration was over 16 μM. We concluded that (i) NO accumulated inside lipid bilayer increases the Cm of s-BLMs, and (ii) C60 inside s-BLMs changes the dielectric constant of lipid bilayer, thus reducing the effect of NO on the Cm of C60@s-BLMs. This novel self-assembled lipid modified probe provides a simple yet interesting model to study the effect of NO on the electrical conductance of the membrane. © 2001 Elsevier Science B.V. All rights reserved.||Source Title:||Electrochemistry Communications||URI:||http://scholarbank.nus.edu.sg/handle/10635/101221||ISSN:||13882481||DOI:||10.1016/S1388-2481(01)00227-2|
|Appears in Collections:||Staff Publications|
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