Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja002073o
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dc.titleNew manzamine alkaloids with potent activity against infectious diseases
dc.contributor.authorEl Sayed, K.A.
dc.contributor.authorKelly, M.
dc.contributor.authorKara, U.A.K.
dc.contributor.authorAng, K.K.H.
dc.contributor.authorKatsuyama, I.
dc.contributor.authorDunbar, D.C.
dc.contributor.authorKhan, A.A.
dc.contributor.authorHamann, M.T.
dc.date.accessioned2014-10-27T08:34:42Z
dc.date.available2014-10-27T08:34:42Z
dc.date.issued2001-03-07
dc.identifier.citationEl Sayed, K.A., Kelly, M., Kara, U.A.K., Ang, K.K.H., Katsuyama, I., Dunbar, D.C., Khan, A.A., Hamann, M.T. (2001-03-07). New manzamine alkaloids with potent activity against infectious diseases. Journal of the American Chemical Society 123 (9) : 1804-1808. ScholarBank@NUS Repository. https://doi.org/10.1021/ja002073o
dc.identifier.issn00027863
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101207
dc.description.abstractThe isolation of the new enantiomers of 8-hydroxymanzamine A (1), manzamine F (2), along with the unprecedented manzamine dimer, neo-kauluamine from an undescribed genus of Indo-Pacific sponge (family Petrosiidae, order Haplosclerida) is reported. The relative stereochemistry of neo-kauluamine was established through detailed analysis of NOE-correlations combined with molecular modeling. The significance of the manzamines as in vivo antimalarial agents with superior activity to the clinically used drugs artemisinin and chloroquine is discussed along with the activity in vitro against the AIDS-opportunistic infectious diseases tuberculosis and toxoplasmosis. Reexamination of the sponges identified as Prianos, and Pachypellina, in earlier publications has confirmed that these are members of the same genus as the sponge described here, but differ at the species level.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ja002073o
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1021/ja002073o
dc.description.sourcetitleJournal of the American Chemical Society
dc.description.volume123
dc.description.issue9
dc.description.page1804-1808
dc.description.codenJACSA
dc.identifier.isiut000167253200002
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