Please use this identifier to cite or link to this item: https://doi.org/10.1002/jnr.21312
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dc.titleNeuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons
dc.contributor.authorTeh, C.H.L.
dc.contributor.authorChin, C.L.
dc.contributor.authorLam, K.K.Y.
dc.contributor.authorJia, M.L.
dc.contributor.authorYan, T.
dc.contributor.authorTit, M.L.
dc.date.accessioned2014-10-27T08:34:36Z
dc.date.available2014-10-27T08:34:36Z
dc.date.issued2007-06
dc.identifier.citationTeh, C.H.L., Chin, C.L., Lam, K.K.Y., Jia, M.L., Yan, T., Tit, M.L. (2007-06). Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of Neuroscience Research 85 (8) : 1762-1773. ScholarBank@NUS Repository. https://doi.org/10.1002/jnr.21312
dc.identifier.issn03604012
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101197
dc.description.abstractCatecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme. Dopamine is the main neurotransmitter present in dopaminergic neurons of the ventral midbrain, where dysfunction of these neurons can lead to Parkinson's disease and schizophrenia. Neuronal PAS domain protein 1 (NPAS1) was identified as one of the genes up-regulated during dopaminergic MN9D cell differentiation. We found that there was a corresponding decrease in TH level during MN9D differentiation. Overexpression and siRNA experiments revealed that NPAS1, in concert with ARNT, negatively regulates the expression of TH and that this regulation is mediated by a direct binding of NPAS1 on the TH promoter. Expression studies also confirmed a decrease in TH level in the ventral midbrain during mouse development, concomitant with an increase in NPAS1 level. These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development. © 2007 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jnr.21312
dc.sourceScopus
dc.subjectDevelopment
dc.subjectNeuronal PAS domain protein 1
dc.subjectTranscriptional regulation
dc.subjectTyrosine hydroxylase
dc.subjectVentral midbrain
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1002/jnr.21312
dc.description.sourcetitleJournal of Neuroscience Research
dc.description.volume85
dc.description.issue8
dc.description.page1762-1773
dc.description.codenJNRED
dc.identifier.isiut000247177400018
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