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|Title:||Nanostructured platinum-lipid bilayer composite as biosensor||Authors:||Ye, J.-S.
Electrochemical impedance spectroscopy
Supported bilayer lipid membrane (s-BLM)
|Issue Date:||Apr-2003||Citation:||Ye, J.-S., Ottova, A., Tien, H.T., Sheu, F.-S. (2003-04). Nanostructured platinum-lipid bilayer composite as biosensor. Bioelectrochemistry 59 (1-2) : 65-72. ScholarBank@NUS Repository. https://doi.org/10.1016/S1567-5394(03)00003-3||Abstract:||The present work describes the preparation of supported bilayer lipid membrane (s-BLM) doped with metal nanoparticles for the design of biosensors. Platinum (Pt) nanoparticles were deposited through s-BLM to build a hybrid device of nanoscale electrode array by potential cycling in 1 mM K2PtCl6 solution containing 0.1 M KCl. The properties of Pt nanoparticle-doped s-BLM composite were then characterized by cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and atomic force microscopy (AFM). Our results showed that Pt nanoparticles grew in voids of the s-BLMs, through which the underlying glassy carbon (GC) electrode was connected, with maximum length extended out of the lipid membrane around 40 nm. Doping of Pt nanoparticles through s-BLM increased the membrane capacitance and decreased the membrane resistance of s-BLM. Pt nanoparticles array in s-BLM electrocatalyzed the reduction of oxygen (O2) in phosphate buffer solution (PBS). Practical application of Pt nanoparticle-doped s-BLM for the construction of glucose biosensor was also demonstrated in terms of its dose-response curve, stability and reproducibility. Thus, lipid membrane doped with Pt nanoparticles is a novel electrode system at nanoscale that can penetrate through the insulating membrane to probe molecular recognition and catalytic events at the lipid membrane-solution interface. © 2003 Elsevier Science B.V. All rights reserved.||Source Title:||Bioelectrochemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/101180||ISSN:||15675394||DOI:||10.1016/S1567-5394(03)00003-3|
|Appears in Collections:||Staff Publications|
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