Please use this identifier to cite or link to this item: https://doi.org/10.1046/j.1440-1681.2002.03725.x
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dc.titleMolecular moulds with multiple missions: Functional sites in three-finger toxins
dc.contributor.authorKini, R.M.
dc.date.accessioned2014-10-27T08:34:01Z
dc.date.available2014-10-27T08:34:01Z
dc.date.issued2002
dc.identifier.citationKini, R.M. (2002). Molecular moulds with multiple missions: Functional sites in three-finger toxins. Clinical and Experimental Pharmacology and Physiology 29 (9) : 815-822. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1440-1681.2002.03725.x
dc.identifier.issn03051870
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101146
dc.description.abstract1. Snake venoms are complex mixtures of pharmacologically active peptides and proteins. 2. These protein toxins belong to a small number of superfamilies of proteins. The present review describes structure-function relationships of three-finger toxins. 3. All toxins share a common structure of three β-stranded loops extending from a central core. However, they bind to different receptors/acceptors and exhibit a wide variety of biological effects. 4. Thus, the structure-function relationships of this group of toxins are complicated and challenging. 5. Studies have shown that the functional sites in these 'sibling' toxins are located on various segments of the molecular surface.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1046/j.1440-1681.2002.03725.x
dc.sourceScopus
dc.subjectCalciseptine
dc.subjectCardiotoxin
dc.subjectCytotoxin
dc.subjectFasciculin
dc.subjectFunctional site
dc.subjectMuscarinic toxin
dc.subjectPost-synaptic neurotoxin
dc.subjectProtein-protein interaction
dc.subjectSnake venom
dc.subjectToxin evolution
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1046/j.1440-1681.2002.03725.x
dc.description.sourcetitleClinical and Experimental Pharmacology and Physiology
dc.description.volume29
dc.description.issue9
dc.description.page815-822
dc.description.codenCEXPB
dc.identifier.isiut000177257600012
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