Please use this identifier to cite or link to this item:
https://doi.org/10.7554/eLife.00640
DC Field | Value | |
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dc.title | miR-124 controls male reproductive success in Drosophila | |
dc.contributor.author | Weng, R. | |
dc.contributor.author | Chin, J.S.R. | |
dc.contributor.author | Yew, J.Y. | |
dc.contributor.author | Bushati, N. | |
dc.contributor.author | Cohen, S.M. | |
dc.date.accessioned | 2014-10-27T08:33:32Z | |
dc.date.available | 2014-10-27T08:33:32Z | |
dc.date.issued | 2013-06-11 | |
dc.identifier.citation | Weng, R., Chin, J.S.R., Yew, J.Y., Bushati, N., Cohen, S.M. (2013-06-11). miR-124 controls male reproductive success in Drosophila. eLife 2013 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.00640 | |
dc.identifier.issn | 2050084X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/101101 | |
dc.description.abstract | Many aspects of social behavior are controlled by sex-specific pheromones. Genderappropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of genderappropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. Copyright Weng et al. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.7554/eLife.00640 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.7554/eLife.00640 | |
dc.description.sourcetitle | eLife | |
dc.description.volume | 2013 | |
dc.description.issue | 2 | |
dc.description.page | - | |
dc.identifier.isiut | 000328616500002 | |
Appears in Collections: | Staff Publications |
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