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https://doi.org/10.7554/eLife.00640
Title: | miR-124 controls male reproductive success in Drosophila | Authors: | Weng, R. Chin, J.S.R. Yew, J.Y. Bushati, N. Cohen, S.M. |
Issue Date: | 11-Jun-2013 | Citation: | Weng, R., Chin, J.S.R., Yew, J.Y., Bushati, N., Cohen, S.M. (2013-06-11). miR-124 controls male reproductive success in Drosophila. eLife 2013 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.00640 | Abstract: | Many aspects of social behavior are controlled by sex-specific pheromones. Genderappropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of genderappropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. Copyright Weng et al. | Source Title: | eLife | URI: | http://scholarbank.nus.edu.sg/handle/10635/101101 | ISSN: | 2050084X | DOI: | 10.7554/eLife.00640 |
Appears in Collections: | Staff Publications |
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