Please use this identifier to cite or link to this item:
|Title:||miR-124 controls male reproductive success in Drosophila||Authors:||Weng, R.
|Issue Date:||11-Jun-2013||Citation:||Weng, R., Chin, J.S.R., Yew, J.Y., Bushati, N., Cohen, S.M. (2013-06-11). miR-124 controls male reproductive success in Drosophila. eLife 2013 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.00640||Abstract:||Many aspects of social behavior are controlled by sex-specific pheromones. Genderappropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of genderappropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. Copyright Weng et al.||Source Title:||eLife||URI:||http://scholarbank.nus.edu.sg/handle/10635/101101||ISSN:||2050084X||DOI:||10.7554/eLife.00640|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 16, 2019
WEB OF SCIENCETM
checked on Oct 8, 2019
checked on Oct 12, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.