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|Title:||Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy||Authors:||Bag, N.
|Issue Date:||14-Oct-2013||Citation:||Bag, N., Ali, A., Chauhan, V.S., Wohland, T., Mishra, A. (2013-10-14). Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy. Chemical Communications 49 (80) : 9155-9157. ScholarBank@NUS Repository.||Abstract:||Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity. © 2013 The Royal Society of Chemistry.||Source Title:||Chemical Communications||URI:||http://scholarbank.nus.edu.sg/handle/10635/101079||ISSN:||13597345|
|Appears in Collections:||Staff Publications|
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