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Title: Mapping the networks for pluripotency
Authors: Xue, K.
Ng, J.-H.
Ng, H.-H. 
Keywords: Embryonic stem cell
Mouse embryonic stem cell-like interconversion
Signalling pathways
Transcriptional network
Issue Date: 4-Jul-2011
Citation: Xue, K., Ng, J.-H., Ng, H.-H. (2011-07-04). Mapping the networks for pluripotency. Philosophical Transactions of the Royal Society B: Biological Sciences 366 (1575) : 2238-2246. ScholarBank@NUS Repository.
Abstract: There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act to sustain the undifferentiated state. Recent studies have unravelled multiple forms of interconnection and crosstalk between these two regulatory aspects of pluripotency. With the discovery of epiblast stem cells, there is an emerging concept that different pluripotent states could exist, and knowledge of both transcriptional networks and signalling pathways has been vital in dissecting the properties of these different states. Similar to classical reprogramming methodologies, various combinations of transcription factor transduction and the modulation of intracellular signalling have enabled the interconversion between pluripotent states. These studies provide an insight into the defining characteristics as well as the plasticity of pluripotent cells. © 2011 The Royal Society.
Source Title: Philosophical Transactions of the Royal Society B: Biological Sciences
ISSN: 09628436
DOI: 10.1098/rstb.2011.0005
Appears in Collections:Staff Publications

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