Please use this identifier to cite or link to this item: https://doi.org/10.1099/vir.0.2008/003681-0
DC FieldValue
dc.titleiTRAQ analysis of Singapore grouper iridovirus infection in a grouper embryonic cell line
dc.contributor.authorChen, L.M.
dc.contributor.authorTran, B.N.
dc.contributor.authorLin, Q.
dc.contributor.authorLim, T.K.
dc.contributor.authorWang, F.
dc.contributor.authorHew, C.-L.
dc.date.accessioned2014-10-27T08:32:21Z
dc.date.available2014-10-27T08:32:21Z
dc.date.issued2008
dc.identifier.citationChen, L.M., Tran, B.N., Lin, Q., Lim, T.K., Wang, F., Hew, C.-L. (2008). iTRAQ analysis of Singapore grouper iridovirus infection in a grouper embryonic cell line. Journal of General Virology 89 (11) : 2869-2876. ScholarBank@NUS Repository. https://doi.org/10.1099/vir.0.2008/003681-0
dc.identifier.issn00221317
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100990
dc.description.abstractWe report, here, the first proteomics study of a grouper embryonic cell line (GEC) infected by Singapore grouper iridovirus (SGIV). The differential proteomes of GEC with and without viral infection were studied and quantified with iTRAQ labelling followed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). Forty-nine viral, proteins were recognized, of which 11 were identified for the first time. Moreover, 743 host proteins were revealed and classified into 218 unique protein groups. Fourteen host proteins were upregulated and five host proteins were downregulated upon viral infection. The iTRAQ analysis of SGIV infection inr GEC provides an insight to viral and host gene products at the protein level. This should facilitate further study and the understanding of virus-host interactions, molecular mechanisms of viral infection and pathogenesis. © 2008 SGM.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1099/vir.0.2008/003681-0
dc.description.sourcetitleJournal of General Virology
dc.description.volume89
dc.description.issue11
dc.description.page2869-2876
dc.description.codenJGVIA
dc.identifier.isiut000260885500026
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