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Title: Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor
Authors: Tan, E.
Low, K.W. 
Wong, W.S.F.
Leung, K.Y. 
Keywords: Aeromonas hydrophila
Fish epithelial cells
Tyrosine kinase
Issue Date: Feb-1998
Citation: Tan, E.,Low, K.W.,Wong, W.S.F.,Leung, K.Y. (1998-02). Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor. Microbiology 144 (2) : 299-307. ScholarBank@NUS Repository.
Abstract: Aeromonas hydrophila is a Gram-negative bacterium that is pathogenic in fish, causing motile aeromonad septicaemia. It can enter (invade) fish cells, and survive as an intracellular parasite. The host-pathogen interaction and signal transduction pathway were studied by screening signal transduction inhibitors using carp epithelial cells and a virulent strain of the bacterium, PPD134/91. Genistein, a tyrosine kinase inhibitor, postponed internalization of A. hydrophila into host cells, suggesting that tyrosine phosphorylation plays a role in internalization. In contrast, staurosporine, a protein kinase C inhibitor, and sodium orthovanadate, a protein tyrosine phosphatase inhibitor, accelerated internalization of PPD134/91. Other virulent strains of A. hydrophila were also examined and it is likely that all strains, irrespective of serogroup, use the same signalling pathway to facilitate bacterial uptake.
Source Title: Microbiology
ISSN: 13500872
Appears in Collections:Staff Publications

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