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Title: Identification of three duplicated Spin genes in medaka (Oryzias latipes)
Authors: Wang, X.-L.
Mei, J.
Sun, M.
Hong, Y.-H. 
Gui, J.-F.
Keywords: Embryogenesis
Functional divergence
Gene duplication
Spindlin (Spin)
Issue Date: 9-May-2005
Citation: Wang, X.-L., Mei, J., Sun, M., Hong, Y.-H., Gui, J.-F. (2005-05-09). Identification of three duplicated Spin genes in medaka (Oryzias latipes). Gene 350 (2) : 99-106. ScholarBank@NUS Repository.
Abstract: Gene and genomic duplications are very important and frequent events in fish evolution, and the divergence of duplicated genes in sequences and functions is a focus of research on gene evolution. Here, we report the identification and characterization of three duplicated Spindlin (Spin) genes from medaka (Oryzias latipes): OlSpinA, OlSpinB, and OlSpinC. Molecular cloning, genomic DNA Blast analysis and phylogenetic relationship analysis demonstrated that the three duplicated OlSpin genes should belong to gene duplication. Furthermore, Western blot analysis revealed significant expression differences of the three OlSpins among different tissues and during embryogenesis in medaka, and suggested that sequence and functional divergence might have occurred in evolution among them. © 2005 Elsevier B.V. All rights reserved.
Source Title: Gene
ISSN: 03781119
DOI: 10.1016/j.gene.2005.02.002
Appears in Collections:Staff Publications

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