Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10529-009-0007-4
Title: Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1
Authors: Hou, H.
Zhang, X.
Tang, T.
Dai, K.
Ge, R. 
Keywords: Angiopoietin-1
Bone morphogenic protein 2
Bone tissue engineering
Critical-size bone defect
Vascular endothelial growth factor
Issue Date: Jul-2009
Citation: Hou, H., Zhang, X., Tang, T., Dai, K., Ge, R. (2009-07). Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1. Biotechnology Letters 31 (8) : 1183-1189. ScholarBank@NUS Repository. https://doi.org/10.1007/s10529-009-0007-4
Abstract: To explore the potential of combined delivery of osteogenic and angiogenic factors to bone marrow stromal cells (BMSCs) for repair of critical-size bone defects, we followed the formation of bone and vessels in tissue-engineered constructs in nude mice and rabbit bone defects upon introducing different combinations of BMP-2, vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) to BMSCs with adenoviral vectors. Better osteogenesis and angiogenesis were found in co-delivery group of BMP-2, VEGF and angiopoietin-1 than any other combination of these factors in both animal models, indicating combined gene delivery of angiopoietin-1 and VEGF165 into a tissue-engineered construct produces an additive effect on BMP-2-induced osteogenesis. © Springer Science+Business Media B.V. 2009.
Source Title: Biotechnology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/100581
ISSN: 01415492
DOI: 10.1007/s10529-009-0007-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

28
checked on Jan 27, 2022

WEB OF SCIENCETM
Citations

26
checked on Jan 18, 2022

Page view(s)

102
checked on Jan 27, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.