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Title: Electrochemical biochip for drug screening at cellular level
Authors: Chen, Y.
Cui, H.-F. 
Ye, J.-S. 
Chong, S.-C.
Lim, T.-M. 
Sheu, F.-S. 
Hui, W.-C.
Keywords: Cell chip
Cell monitoring
Drug screening
In situ
Microelectrode array
Temporal detection
Issue Date: 1-Apr-2006
Citation: Chen, Y., Cui, H.-F., Ye, J.-S., Chong, S.-C., Lim, T.-M., Sheu, F.-S., Hui, W.-C. (2006-04-01). Electrochemical biochip for drug screening at cellular level. Journal of Physics: Conference Series 34 (1) : 198-203. ScholarBank@NUS Repository.
Abstract: Drug screening at cellular level has becomes an attractive field of research. Different researchers have tried to record cellular response to drugs by electrical or optical approach using both invasive and non-invasive methods. Silicon-based microelectrode integrated microchips are useful tools for in situ temporal recording of neurotransmitter releasing from neural cells. A microfabricated electrochemical biochip is presented in this paper. Using dopaminergic cells grown on the chip, the dopamine excytosis can be electrochemical amperomatric detected non-invasively from drug incubated dopaminegic cells by the microelectrode integrated on chip. This silicon-based electrochemical chip has been designed with an electrode array located on the cell culture chamber bottom. Each electrode is individually electrical controlled. MN9D and PC12 dopaminergic cell lines have been demonstrated on this chip for drug effects study. This silicon-based electrochemical microchip provides a non-invasive, in situ, temporal detection of dopamine exocytosis from dopaminegic cells, and holds the potential for applications in studying the mechanisms of dopamine exocytosis and drug screening. It is also extendable for other cell culture and drug effects study. © 2006 IOP Publishing Ltd.
Source Title: Journal of Physics: Conference Series
ISSN: 17426588
DOI: 10.1088/1742-6596/34/1/033
Appears in Collections:Staff Publications

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