Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/100466
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dc.titleDifferential signal transduction, membrane trafficking, and immune effector functions mediated by FcγRI versus FcγRIIa
dc.contributor.authorDai, X.
dc.contributor.authorJayapal, M.
dc.contributor.authorHwee, K.T.
dc.contributor.authorReghunathan, R.
dc.contributor.authorLin, G.
dc.contributor.authorChien, T.T.
dc.contributor.authorYan, T.L.
dc.contributor.authorSoh, H.C.
dc.contributor.authorKemeny, D.M.
dc.contributor.authorFloto, R.A.
dc.contributor.authorSmith, K.G.C.
dc.contributor.authorMelendez, A.J.
dc.contributor.authorMacAry, P.A.
dc.date.accessioned2014-10-27T08:26:10Z
dc.date.available2014-10-27T08:26:10Z
dc.date.issued2009
dc.identifier.citationDai, X., Jayapal, M., Hwee, K.T., Reghunathan, R., Lin, G., Chien, T.T., Yan, T.L., Soh, H.C., Kemeny, D.M., Floto, R.A., Smith, K.G.C., Melendez, A.J., MacAry, P.A. (2009). Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcγRI versus FcγRIIa. Blood 114 (2) : 318-327. ScholarBank@NUS Repository.
dc.identifier.issn00064971
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100466
dc.description.abstractReceptors for the fragment crystallizable region of immunoglobulin-G (FcγRs) play an important role in linking the humoral and cellular arms of the immune response. In this study, we present a comprehensive functional comparison of 2 human Fc-receptors, FcγRI and FcγRIIa. Activation of FcγRI results in a novel signaling cascade that links phospholipase D1 to sphingosine kinase-1 in U937 cells and primary human monocytes. This induces the expression of proinflammatory mediators and is associated with trafficking of immune complexes into human leukocyte antigen-DM positive antigen-processing compartments coupled with improved MHC class II-mediated antigen presentation to T lymphocytes. In contrast, activation of FcγRIIa elicits signaling through phospholipase Cγ1, resulting in increases in intracellular calcium, activation of nicotinamide adenine dinucleotide phosphate-oxidative burst, and differential membrane trafficking combined with impaired antigen presentation and proinflammatory cytokine expression. These data provide a mechanistic insight into the disparate activities associated with Fc receptors in immunity, namely, reinforcement of immune responses through stimulation of proinflammatory signaling and antigen presentation, versus the maintenance of immunologic homeostasis through the noninflammatory clearance of immune complexes. © 2009 by The American Society of Hematology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1182/blood-2008-10-184457
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.sourcetitleBlood
dc.description.volume114
dc.description.issue2
dc.description.page318-327
dc.description.codenBLOOA
dc.identifier.isiut000268061700017
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