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Title: Dexamethasone receptors and their distribution in the brain of the red tilapia
Authors: Chen, K.M.
Chan, W.K. 
Munro, A.D. 
Keywords: Brain
Cortisol receptors
Issue Date: 1997
Citation: Chen, K.M., Chan, W.K., Munro, A.D. (1997). Dexamethasone receptors and their distribution in the brain of the red tilapia. Fish Physiology and Biochemistry 16 (3) : 171-179. ScholarBank@NUS Repository.
Abstract: Cytosolic extracts of liver and brain showed specific, saturable binding with [3H]dexamethasone: Scatchard plots were linear. Cortisol and 11-deoxycortisol acted as competitors, whilst 17α,20α-dihydroxy-4-pregnen-3-one was relatively much less effective. There was a four-fold range of differences in specific binding capacity between dissected brain regions, the order being telencephalon > hypothalamus > rhombencephalon > optic tectum ≈ (thalamus + tegmentum + torus semicircularis) when Nmax was calculated in terms of DNA content. There was no evidence for any binding of [3H]dexamethasone with membrane fractions.
Source Title: Fish Physiology and Biochemistry
ISSN: 09201742
Appears in Collections:Staff Publications

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