Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.devcel.2010.10.024
Title: DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs
Authors: Hou, X. 
Lee, L.Y.C.
Xia, K.
Yan, Y.
Yu, H. 
Issue Date: 14-Dec-2010
Citation: Hou, X., Lee, L.Y.C., Xia, K., Yan, Y., Yu, H. (2010-12-14). DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs. Developmental Cell 19 (6) : 884-894. ScholarBank@NUS Repository. https://doi.org/10.1016/j.devcel.2010.10.024
Abstract: Gibberellins (GAs) modulate jasmonate (JA) signaling, which is essential for stress response and development in plants. However, the molecular details of such phytohormone interaction remain largely unknown. Here, we show that the JA ZIM-domain 1 (JAZ1) protein, a key repressor of JA signaling, interacts in vivo with DELLA proteins, repressors of the GA pathway. DELLAs prevent inhibitory JAZ1 interaction with a key transcriptional activator of JA responses, MYC2, and, thus, enhance the ability of MYC2 to regulate its target genes. Conversely, GA triggers degradation of DELLAs, which allows JAZ1 to bind MYC2 and suppress MYC2-dependent JA-signaling outputs. Therefore, our results reveal one means by which GAs suppress cellular competence to respond to JA. Because DELLAs serve as central regulators that mediate the crosstalk of various phytohormones, our model also suggests a candidate mechanism by which JA signaling may be fine-tuned by other signaling pathways through DELLAs. © 2010 Elsevier Inc.
Source Title: Developmental Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/100413
ISSN: 15345807
DOI: 10.1016/j.devcel.2010.10.024
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