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|Title:||Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus||Authors:||Praseuth, A.P.
Nonribosomal peptide synthetase
|Issue Date:||Nov-2008||Citation:||Praseuth, A.P., Wang, C.C.C., Watanabe, K., Hotta, K., Oguri, H., Oikawa, H. (2008-11). Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress 24 (6) : 1226-1231. ScholarBank@NUS Repository. https://doi.org/10.1002/btpr.34||Abstract:||Streptomyces triostinicus produces triostin A, an antitumor antibiotic, as its major secondary metabolite. Surprisingly, this strain also produced a trace amount of echinomycin. We sequenced the entire triostin A biosynthetic gene cluster from S. triostinicus, and found that this 36 kilobase-long gene cluster contained an ORF homologous to ecm18 that encodes a thioacetal-forming enzyme responsible for the triostin A-to-echinomycin bioconversion. These findings indicate that, unlike previously thought, S. triostinicus is capable of producing not only triostin A but also echinomycin. Our observation suggests potential value in careful reanalysis for metabolites from previously characterized natural product producers with the current technologies. © 2008 American Institute of Chemical Engineers.||Source Title:||Biotechnology Progress||URI:||http://scholarbank.nus.edu.sg/handle/10635/100311||ISSN:||87567938||DOI:||10.1002/btpr.34|
|Appears in Collections:||Staff Publications|
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