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|Title:||Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata||Authors:||Ito, C.
Cancer chemopreventive agents
|Issue Date:||Jan-2004||Citation:||Ito, C.,Itoigawa, M.,Kojima, N.,Tan, H.T.-W.,Takayasu, J.,Tokuda, H.,Nishino, H.,Furukawa, H. (2004-01). Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata. Planta Medica 70 (1) : 8-11. ScholarBank@NUS Repository.||Abstract:||A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aα,12aα-12a-hydroxyelliptone (3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of β-carotene without any cytotoxicity. Deguelin (4) and α-toxicarol (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.||Source Title:||Planta Medica||URI:||http://scholarbank.nus.edu.sg/handle/10635/100210||ISSN:||00320943|
|Appears in Collections:||Staff Publications|
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