Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.dci.2009.05.008
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dc.titleBombyx mori transferrin: Genomic structure, expression and antimicrobial activity of recombinant protein
dc.contributor.authorYun, E.-Y.
dc.contributor.authorLee, J.-K.
dc.contributor.authorKwon, O.-Y.
dc.contributor.authorHwang, J.-S.
dc.contributor.authorKim, I.
dc.contributor.authorKang, S.-W.
dc.contributor.authorLee, W.-J.
dc.contributor.authorDing, J.L.
dc.contributor.authorYou, K.-H.
dc.contributor.authorGoo, T.-W.
dc.date.accessioned2014-10-27T08:23:00Z
dc.date.available2014-10-27T08:23:00Z
dc.date.issued2009-10
dc.identifier.citationYun, E.-Y., Lee, J.-K., Kwon, O.-Y., Hwang, J.-S., Kim, I., Kang, S.-W., Lee, W.-J., Ding, J.L., You, K.-H., Goo, T.-W. (2009-10). Bombyx mori transferrin: Genomic structure, expression and antimicrobial activity of recombinant protein. Developmental and Comparative Immunology 33 (10) : 1064-1069. ScholarBank@NUS Repository. https://doi.org/10.1016/j.dci.2009.05.008
dc.identifier.issn0145305X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100186
dc.description.abstractTransferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates. Although transferrin has been suggested to play a role in innate immunity, its immunological function during infection has not been characterized. In this study, we identified and characterized Bombyx mori transferrin (BmTf). The promoter region of BmTf has numerous putative NF-κB binding sites, suggesting its possible function in innate immunity. Analysis of BmTf gene expression shows that it is highly inducible in response to a wide variety of pathogens including bacteria, fungus, and viruses. Recombinant BmTf protein produced in a baculovirus system exhibits iron binding capacity and antibacterial activity against various Gram-positive and -negative bacteria. Taken together, our results indicate that BmTf is an inducible immune effector molecule that may play an important role in pathogen clearance of insect innate immunity. © 2009 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.dci.2009.05.008
dc.sourceScopus
dc.subjectAntimicrobial activity
dc.subjectBombyx mori
dc.subjectInnate immunity
dc.subjectTransferrin
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.dci.2009.05.008
dc.description.sourcetitleDevelopmental and Comparative Immunology
dc.description.volume33
dc.description.issue10
dc.description.page1064-1069
dc.description.codenDCIMD
dc.identifier.isiut000268952800003
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