Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/100169
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dc.titleBioactivity Screening of Singapore Gorgonians: Antimicrobial Activity, Toxicity to Artemia salina and Efficacy against Plasmodium berghei
dc.contributor.authorGoh, N.K.C.
dc.contributor.authorChou, L.M.
dc.date.accessioned2014-10-27T08:22:49Z
dc.date.available2014-10-27T08:22:49Z
dc.date.issued1998-10
dc.identifier.citationGoh, N.K.C.,Chou, L.M. (1998-10). Bioactivity Screening of Singapore Gorgonians: Antimicrobial Activity, Toxicity to Artemia salina and Efficacy against Plasmodium berghei. Zoological Science 15 (5) : 805-812. ScholarBank@NUS Repository.
dc.identifier.issn02890003
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100169
dc.description.abstractNine of ten gorgonian extracts from all four families tested showed antimicrobial activity. Inhibition of Gram positive bacteria was more widespread than that of Gram negative bacteria. Inhibition of the yeast Saccharomyces cerevisiae was confined to (and widespread within) the family Ellisellidae. No antifungal activity against Aspergillus sp. was found in all the extracts tested. Acute (6 hr) and chronic (24 hr) extract toxicity towards Artemia salina varied between extracts and showed no taxonomic correlations; compared to potassium dichromate, extract toxicity was low. Chronic exposure to the extracts was more effective in killing A. salina; chronic LD50 values ranged from 3.2 to 125.9 mg/ml. All ten extracts failed to extend survival, lower percentage parasitemia or affect parasite morphology in Plasmodium berghei-infected mice.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.sourcetitleZoological Science
dc.description.volume15
dc.description.issue5
dc.description.page805-812
dc.description.codenZOSCE
dc.identifier.isiutNOT_IN_WOS
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