Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.exphem.2010.11.009
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dc.titleBIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia
dc.contributor.authorJiang, N.
dc.contributor.authorKoh, G.S.
dc.contributor.authorSuang Lim, J.Y.
dc.contributor.authorYin Kham, S.K.
dc.contributor.authorAriffin, H.
dc.contributor.authorChew, F.T.
dc.contributor.authorJuh Yeoh, A.E.
dc.date.accessioned2014-10-27T08:22:45Z
dc.date.available2014-10-27T08:22:45Z
dc.date.issued2011-03
dc.identifier.citationJiang, N., Koh, G.S., Suang Lim, J.Y., Yin Kham, S.K., Ariffin, H., Chew, F.T., Juh Yeoh, A.E. (2011-03). BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia. Experimental Hematology 39 (3) : 321-329.e3. ScholarBank@NUS Repository. https://doi.org/10.1016/j.exphem.2010.11.009
dc.identifier.issn0301472X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100163
dc.description.abstractObjective: Glucocorticoids such as prednisolone (PRED) are widely used in the treatment of pediatric acute lymphoblastic leukemia. In PRED-induced apoptosis, Bcl-2 family members play important regulatory roles. However, the exact members involved remain unknown. In this study, the roles of Bcl-2 family members in PRED-induced apoptosis and their prognostic value to day 8 PRED response are evaluated. Materials and Methods: Four clinically important acute lymphoblastic leukemia cell lines, three PRED-sensitive (697, Sup-B15, and RS4;11) and one PRED-resistant (REH) were studied. Thirty paired patient bone marrow samples were obtained at diagnosis (day 0) and after 7 days (day 8) of PRED monotherapy. Twenty-five patients had PRED good response and five PRED poor response. Differential expressions of Bcl-2 members were observed in those samples and BIM was further investigated using gene silencing technology in representative cell line Sup-B15. Results: The proapoptotic BH3-only Bcl-2 family member BIM was upregulated only in PRED-sensitive cells. Receiver operating characteristic curve analysis showed that BIM expression was highly predictive of PRED response (area under the curve = 0.81; p = 0.032) in paired patient bone marrow samples and is, most excitingly, independent of molecular subtype. Patients whose BIM protein expression levels fail to upregulate at day 8 compared to day 0 (D8/D0 ratio
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.exphem.2010.11.009
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.exphem.2010.11.009
dc.description.sourcetitleExperimental Hematology
dc.description.volume39
dc.description.issue3
dc.description.page321-329.e3
dc.description.codenEXHEB
dc.identifier.isiut000288288200006
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