Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3835(00)00331-1
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dc.titleAnti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
dc.contributor.authorIto, C.
dc.contributor.authorItoigawa, M.
dc.contributor.authorTan, H.T.W.
dc.contributor.authorTokuda, H.
dc.contributor.authorYang Mou, X.
dc.contributor.authorMukainaka, T.
dc.contributor.authorIshikawa, T.
dc.contributor.authorNishino, H.
dc.contributor.authorFurukawa, H.
dc.date.accessioned2014-10-27T08:22:01Z
dc.date.available2014-10-27T08:22:01Z
dc.date.issued2000-05-01
dc.identifier.citationIto, C., Itoigawa, M., Tan, H.T.W., Tokuda, H., Yang Mou, X., Mukainaka, T., Ishikawa, T., Nishino, H., Furukawa, H. (2000-05-01). Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Letters 152 (2) : 187-192. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(00)00331-1
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100101
dc.description.abstractAs a part of screening studies for anti-tumor promoters, fifteen isoflavonoids isolated from plants of the genus Millettia (Leguminosae) were evaluated by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Auriculasin (11) and millepurone (13), which is an oxidized isoflavone analogue, both having one or more prenyl side-chains and a 3',4'-dihydroxyphenyl group in the molecule, showed more potent activity than any of the other compounds tested. Furthermore, millepurone (13) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these isoflavonoids might be valuable anti-tumor promoters. Copyright (C) 2000 Elsevier Science Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(00)00331-1
dc.sourceScopus
dc.subjectAnti-tumor-promoting effect
dc.subjectEpstein-Barr virus activation test
dc.subjectIsoflavonoids
dc.subjectStructure-activity relationships
dc.subjectTwo-stage mouse skin carcinogenesis test
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/S0304-3835(00)00331-1
dc.description.sourcetitleCancer Letters
dc.description.volume152
dc.description.issue2
dc.description.page187-192
dc.description.codenCALED
dc.identifier.isiut000166661300011
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