Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ccr.2011.01.018
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dc.titleAngiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2-:H2O2 Ratio and Confers Anoikis Resistance to Tumors
dc.contributor.authorZhu, P.
dc.contributor.authorTan, M.
dc.contributor.authorHuang, R.-L.
dc.contributor.authorTan, C.
dc.contributor.authorChong, H.
dc.contributor.authorPal, M.
dc.contributor.authorLam, C.
dc.contributor.authorBoukamp, P.
dc.contributor.authorPan, J.
dc.contributor.authorTan, S.
dc.contributor.authorKersten, S.
dc.contributor.authorLi, H.
dc.contributor.authorDing, J.
dc.contributor.authorTan, N.
dc.date.accessioned2014-10-27T08:21:54Z
dc.date.available2014-10-27T08:21:54Z
dc.date.issued2011-03-08
dc.identifier.citationZhu, P., Tan, M., Huang, R.-L., Tan, C., Chong, H., Pal, M., Lam, C., Boukamp, P., Pan, J., Tan, S., Kersten, S., Li, H., Ding, J., Tan, N. (2011-03-08). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2-:H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer Cell 19 (3) : 401-415. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ccr.2011.01.018
dc.identifier.issn15356108
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100091
dc.description.abstractCancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O 2 -. A high ratio of O 2 -:H 2O 2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O 2 - production and a reduced O 2 -:H 2O 2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target. © 2011 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ccr.2011.01.018
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.ccr.2011.01.018
dc.description.sourcetitleCancer Cell
dc.description.volume19
dc.description.issue3
dc.description.page401-415
dc.description.codenCCAEC
dc.identifier.isiut000288642500012
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