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|Title:||Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model||Authors:||Shim, W.S.N.
|Issue Date:||Jul-2006||Citation:||Shim, W.S.N., Li, W., Zhang, L., Li, S., Ong, H.C., Song, I.-C., Bapna, A., Ge, R., Lim, Y.T., Chuah, S.C., Sim, E.K.W., Wong, P. (2006-07). Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. Journal of Biomedical Science 13 (4) : 579-591. ScholarBank@NUS Repository.||Abstract:||This study investigates the long-term angiogenic effects of ANG-1 and VEGF in a swine chronic myocardial ischemia model. Four-weeks after gradual occlusion of the left circumflex coronary artery by ameroid constrictor, animals were injected with recombinant adenoviral vectors carrying either human ANG-1 (n=9), human VEGF165 (n=10) or empty vector (n=7) into the left ventricle free wall supplied by the constricted artery. Left ventricular perfusion in animals that received AdANG-1 (3.25±0.16 ml/min/g, p||Source Title:||Journal of Biomedical Science||URI:||http://scholarbank.nus.edu.sg/handle/10635/100088||ISSN:||10217770|
|Appears in Collections:||Staff Publications|
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