Please use this identifier to cite or link to this item: https://doi.org/10.1006/excr.2002.5597
DC FieldValue
dc.titleAngiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice
dc.contributor.authorShim, W.S.N.
dc.contributor.authorTeh, M.
dc.contributor.authorBapna, A.
dc.contributor.authorKim, I.
dc.contributor.authorKoh, G.-Y.
dc.contributor.authorMack, P.O.P.
dc.contributor.authorGe, R.
dc.date.accessioned2014-10-27T08:21:51Z
dc.date.available2014-10-27T08:21:51Z
dc.date.issued2002
dc.identifier.citationShim, W.S.N., Teh, M., Bapna, A., Kim, I., Koh, G.-Y., Mack, P.O.P., Ge, R. (2002). Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Experimental Cell Research 279 (2) : 299-309. ScholarBank@NUS Repository. https://doi.org/10.1006/excr.2002.5597
dc.identifier.issn00144827
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100086
dc.description.abstractAngiopoietins have been increasingly implicated to play important roles in blood vessel formation, remodeling, maturation, and maintenance. However, their roles in tumor angiogenesis and hence tumor growth and metastasis still remain uncertain. In this work, angiopoietin 1 expression was amplified in human cervical cancer HeLa cells by stable transfection or recombinant human adenovirus-mediated gene transfer. We show that increased angiopoietin 1 expression promoted in vivo growth of human cervical cancers in mice by promoting tumor angiogenesis and inhibiting tumor cell apoptosis. Furthermore, we also show for the first time that overexpression of angiopoietin 1 also leads to increased tumor vessel plasticity with a large number of vessels lacking periendothelial supporting cells. These results indicate that angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. © 2002 Elsevier Science (USA).
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1006/excr.2002.5597
dc.sourceScopus
dc.subjectAngiopoietin 1
dc.subjectTumor angiogenesis
dc.subjectVessel plasticity
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1006/excr.2002.5597
dc.description.sourcetitleExperimental Cell Research
dc.description.volume279
dc.description.issue2
dc.description.page299-309
dc.description.codenECREA
dc.identifier.isiut000178224700013
Appears in Collections:Staff Publications

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