Please use this identifier to cite or link to this item: https://doi.org/10.3109/10253890.2010.506931
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dc.titleAcute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function
dc.contributor.authorWang, C.-M.
dc.contributor.authorAlmsherqi, Z.A.
dc.contributor.authorMcLachlan, C.S.
dc.contributor.authorMatthews, S.
dc.contributor.authorRamachandran, M.
dc.contributor.authorTay, S.K.
dc.contributor.authorDeng, Y.
dc.date.accessioned2014-10-27T08:20:58Z
dc.date.available2014-10-27T08:20:58Z
dc.date.issued2011-01
dc.identifier.citationWang, C.-M., Almsherqi, Z.A., McLachlan, C.S., Matthews, S., Ramachandran, M., Tay, S.K., Deng, Y. (2011-01). Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function. Stress 14 (1) : 66-72. ScholarBank@NUS Repository. https://doi.org/10.3109/10253890.2010.506931
dc.identifier.issn10253890
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100007
dc.description.abstractAssociations between uncoupling protein (UCP) expression and functional changes in myocardial mitochondrial bio-energetics have not been well studied during periods of starvation stress. Our aim was to study the effects of acute starvation, for 24 or 48 h, on combined cardiac mitochondrial function and UCP expression in mice. Isolated heart mitochondria from female mice starved for 48 h compared to that from mice fed revealed a significantly (p < 0.05) decreased adenosine diphosphate-to-oxygen ratio, a significantly increased proton leak and an increased GTP inhibition on palmitic acid-induced state 4 oxygen consumption (p < 0.05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression. In conclusion, our findings suggest that increased UCP2 and UCP3 levels may contribute to decreased myocardial mitochondrial bio-energetic function due to starvation. © 2010 Informa Healthcare USA, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3109/10253890.2010.506931
dc.sourceScopus
dc.subjectCardiac myocytes
dc.subjectmitochondrial bio-energetics
dc.subjectoxidative stress
dc.subjectstarvation
dc.subjectuncoupling protein
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.3109/10253890.2010.506931
dc.description.sourcetitleStress
dc.description.volume14
dc.description.issue1
dc.description.page66-72
dc.description.codenSTREF
dc.identifier.isiut000285422400008
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