Citations
Altmetric:
Alternative Title
Abstract
Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies in the engineering and structural characterization of PKSs have facilitated the use of target enzymes as biocatalysts to produce novel functionally optimized polyketides. These compounds may serve as potential drug leads. This review summarizes the insights gained from research on type III PKSs, from the discovery of chalcone synthase in plants to novel PKSs in bacteria and fungi. To date, at least 15 families of type III PKSs have been characterized, highlighting the utility of PKSs in the development of natural product libraries for therapeutic development. © 2016 by the authors; licensee MDPI.
Keywords
acyl coenzyme A, acyltransferase, chalcone synthase, enzyme, bacterium, chemistry, enzymology, fungus, metabolism, Acyl Coenzyme A, Acyltransferases, Bacteria, Enzymes, Fungi
Source Title
Molecules
Publisher
MDPI AG
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2016
DOI
10.3390/molecules21060806
Type
Review