Solid-phase synthesis of peptidomimetic oligomers with a phosphodiesterase backbone
Lin, P. Ganesan, A.
Lin, P.
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Abstract
An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.
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Source Title
Bioorganic and Medicinal Chemistry Letters
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Date
1998-03-03
DOI
10.1016/S0960-894X(98)00064-X
Type
Article