Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum
Itoigawa, M. Ito, C. Tan, H.T.-W. Kuchide, M. Tokuda, H. Nishino, H. Furukawa, H.
Itoigawa, M.
Ito, C.
Kuchide, M.
Tokuda, H.
Nishino, H.
Furukawa, H.
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Abstract
In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd.
Keywords
4-Phenylcoumarins, Anti-tumor-promoting effect, Calophyllum inophyllum, Cancer chemopreventive agents, Epstein-Barr virus activation, Two-stage mouse skin carcinogenesis
Source Title
Cancer Letters
Publisher
Series/Report No.
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Date
2001-08-10
DOI
10.1016/S0304-3835(01)00521-3
Type
Article