Highly efficient threonine-derived organocatalysts for direct asymmetrie aldol reactions in water
Wu, X. Jiang, Z. Shen, H.-M. Lu, Y.
Jiang, Z.
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Abstract
The introduction of siloxy groups at the hydroxy function of natural threonine resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of both cyclic and acyclic ketones with aromatic aldehydes in water with excellent enantiomeric excess. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA,.
Keywords
Aldol reaction, Asymmetric catalysis, Hydrophobic effect, Organic catalysis, Water
Source Title
Advanced Synthesis and Catalysis
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Series/Report No.
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Date
2007-04
DOI
10.1002/adsc.200600564
Type
Article