SYNAPTIC PLASTICITY AND ASSOCIATIVITY MEDIATED BY DOPAMINERGIC SIGNALING IN ADULT AND AGED HIPPOCAMPAL CA1 PYRAMIDAL NEURONS: AN IN VITRO ELECTROPHYSIOLOGICAL STUDY
MAHESH SHIVARAMA SHETTY
MAHESH SHIVARAMA SHETTY
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Abstract
ALTERED DOPAMINERGIC SIGNALING IS IMPLICATED IN THE PATHOPHYSIOLOGY OF MANY NEUROPSYCHIATRIC DISORDERS AND IN THE AGE-ASSOCIATED MEMORY DEFICITS. IN THIS STUDY, USING CELLULAR MODELS OF MEMORY DIFFERENTIAL INFLUENCE OF DOPAMINERGIC MECHANISMS ON CELLULAR MEMORY CONSOLIDATION WAS INVESTIGATED. THE RESULTS SHOW THAT IN CA1 PYRAMIDAL NEURONS, DOPAMINE D1/D5 RECEPTOR ACTIVATION LEADS TO DOSE-DEPENDENT, DIFFERENTIAL INTRACELLULAR MECHANISMS WHICH SIGNIFICANTLY INFLUENCE THE ONGOING ASSOCIATIVE INFORMATION PROCESSING. IN THE SECOND PART, AGING-ASSOCIATED ALTERATIONS IN THE SYNAPTIC PLASTICITY PROCESSES WAS INVESTIGATED. EVIDENCE IS PROVIDED TO SHOW THE DEFICITS IN DOPAMINERGIC SIGNALING-DEPENDENT LTP AND ASSOCIATIVITY OF CELLULAR CONSOLIDATION. POSSIBLE ROLE OF INCREASED HIPPOCAMPAL ZN2+ LEVELS AS A CONTRIBUTING FACTOR FOR AGE-RELATED MEMORY DEFICITS WAS INVESTIGATED AND THE RESULTS SHOW PROMISING RESCUE OF DEFICITS IN CELLULAR ASSOCIATIVE MEMORY PROCESSES FOLLOWING TREATMENT WITH A CELL-PER
Keywords
Dopamine, Synaptic Plasticity, Aging, Memory, LTP, Synaptic tagging
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Date
2016-01-22
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