Finding functional promoter motifs by computational methods: A word of caution
Chowdhary, R. Wong, L. Bajic, V.B.
Chowdhary, R.
Bajic, V.B.
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Abstract
The standard practice in the analysis of promoters is to select promoter regions of convenient length. This may lead to false results when searching for Transcription Factor Binding Sites (TFBSs), since the sequences may contain coding segments. In such cases, motif detection may single out motifs from the coding regions. The mapping of TFBSs to promoters may result in a misleading picture of 'promoter' content. We illustrate these issues using the example of histones H2A and H2B and show how such analysis could be misleading if care is not exercised to eliminate coding regions from the presumed promoter sequences. Copyright © 2006 Inderscience Enterprises Ltd.
Keywords
Motifs, Promoter, Transcription Factor Binding Sites (TFBSs), Transcription Start Sites (TSSs), Translation Initiation Sites (TIS)
Source Title
International Journal of Bioinformatics Research and Applications
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Date
2006
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Article