Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets
Khor, E. Tay, L.F. Goh, K.S. Lee, C.N.
Tay, L.F.
Goh, K.S.
Lee, C.N.
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Alternative Title
Abstract
A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
Keywords
Drug delivery, Endocarditis, Gentamicin, Prosthetic heart valves
Source Title
Biomaterials
Publisher
Series/Report No.
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Date
1996-08
DOI
10.1016/0142-9612(95)00317-7
Type
Article