Characterisation of soluble murine CD137 and its association with systemic lupus
Shao, Z. Sun, F. Koh, D.R. Schwarz, H.
Shao, Z.
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Alternative Title
Abstract
CD137 is a member of the tumor necrosis factor receptor family, and is involved in the regulation of activation, proliferation, differentiation and apoptosis of T cells, B cells, monocytes, dendritic cells, natural killer cells and granulocytes. Here report that soluble forms of murine CD137 (sCD137) are generated by differential splicing and are released by activated T cells. Levels of sCD137 correlate with cell activation and the extent of cell death but not with cellular proliferation. While CD8+ T cells express significantly more cell surface CD137 than CD4+ T cells, both T cell subsets express similar levels of sCD137, resulting a twofold increased ratio of soluble to cell surface CD137 for CD4+ T cells. sCD137 exists as a trimer and a higher order multimer, can bind to CD137 ligand, and inhibits secretion of IL-10 and IL-12. sCD137 is present in sera of mice with autoimmune disease but is undetectable in sera of healthy mice. © 2008 Elsevier Ltd. All rights reserved.
Keywords
Autoimmune, CD137, Cytokine receptor, Systemic lupus erythematousus
Source Title
Molecular Immunology
Publisher
Series/Report No.
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Date
2008
DOI
10.1016/j.molimm.2008.05.028
Type
Article